Projeler

BİLİMSEL ARAŞTIRMA PROJELERİ, BİLİM VE TEKNOLOJİDE ULUSLARARASI İŞBİRLİKLERİ

SCIENTIFIC RESEARCH PROJECTS, INTERNATIONAL COLLABORATIONS IN SCIENCE AND TECHNOLOGY

ULUSLARARASI/İKİLİ İŞBİRLİĞİ ÇAĞRILARI

INTERNATIONAL/BILATERAL

2021-                   Near-infrared-responsive Ce-Bi@ZIF-8 hybrid nanocomposite for treatment of amyloid-β (Aβ) neurotoxicity: A rational road map against Alzheimer’s disease. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Centre for International Scientific Cooperation of the Ministry of Science, Research and Technology /CISC - İRAN MSRT. 121R003

2016-2021      Targeting cannabinoid receptor signalling in inflammatory neurodegeneration: a potential role for redox-mediated pathways. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Meksika-CONACYT. No: 315S088.

2016-2020         Targeting Molecular Pathways of Glycolipotoxicity by a Novel Carboxymethylated Mercaptotriazinoindole Inhibitor of Aldo-Keto Reductase AKR1B1  In Diabetes, Inflammation  and Age-related Neurodegeneration. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Slovak Academy of Sciences, SBAG-SLOVAK No: 215S197.

2008-2011          The role of oxidative stress in apoptosis and dysfunction of pancreatic beta cells: The potential protective effect of novel pyridoindole antioxidants. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Slovak Academy of Sciences, TUBITAK-SLOVAK No: 108S239.

2003-2006        Antioxidants and aldose reductase blockade in prevention of late diabetic complications: study on new pyridoindole derivatives. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) and Slovak Academy of Sciences, SBAG-SLOVAK No: 103S180.

EU COST PROJELERİ

EU COST PROJECTS (EUROPEAN COOPERATION IN SCIENCE AND TECHNOLOGY)

2016 - 2021        Personalized Nutrition in Aging Society: Redox Control of Major Age-Related Diseases.European Cooperation in Science and Technology, COST Action CA16112: International coordinator: Prof. Mustapha Cherkaoui, France. Management Committee Member, MC: C. Karasu, PhD., Faculty of Medicine, Gazi University, Ankara.

2012 – 2016       EU-ROS. Reactive Oxygen Species, COST Action BM1203: International coordinator: Prof. Andreas DAIBER, Germany.  Management Committee Member, MC: C. Karasu, PhD., Faculty of Medicine, Gazi University, Ankara.

2010 – 2014       Chemistry of nonenzymatic protein modification – modulation of protein structure and function, COST Action CM1001: Management Committee Member, MC: N. Kartal Özer, PhD., Faculty of Medicine, Marmara University, İstanbul. Contributor: C. Karasu, PhD., Faculty of Medicine, Gazi University, Ankara.

2006 – 2010       Lipid peroxidation associated disorders LPO, COST Action B35: International coordinator: Prof. Neven Žarkovič, Croatia. Management Committee Member, MC: C. Karasu, PhD., Faculty of Medicine, Gazi University, Ankara.

TÜBİTAK/ULUSAL

2021 -               Targeting Signaling Pathways of Alzheimer’s Disease Pathology by Oleuropein-loaded nanostructured lipid carrier. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1001 SBAG No: 606673.

2016-2020       Investigation of Regenerative Effects and Action Mechanisms of Redox Modulator Agents in the Pathogenesis of Osteoarthritis. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK), 1001 SBAG No: 315S012.

2013-2016         Investigation of the effects of phenolic phytochemicals on endoplasmic reticulum stress and apoptosis mechanisms in an in vitro model of Parkinson’s disease. Supported by the Scientific and Technological Research Council of Turkey (TUBITAK), 1002 KBAG No: 114Z465.

2006-2010         Research on effects of Olea europaea leaf extracts on protein-lipid oxidation, apoptosis signal transduction pathways and glucose stimulated insulin release in INS-1E pancreas beta cell line. Supported by Scientific and Technological Research Council of Turkey (TUBITAK) 1001 SBAG No: 106S025.

2001-2005       Antioxidants and aldose reductase blockade in  prevention of late diabetic complications: study on new pyridoindole derivatives. Supported by Turkish Scientific and Research Council (TUBITAK), 1001 SBAG No: 100S232.

BAP/ULUSAL

2020-              Fruktoz + STZ-Diyabet Modeliyle İndüklenen Göz Hasarları Üzerinde Aldoz Redüktaz İnhibitörü Bileşiklerin Etkileri. Supported by Gazi University Research Foundation No: (01/2019-25).

2018-2020    Investigation of Regenerative Effects and Mechanisms of Action of the Polyphenolic Compounds on Redox Stress Mediated Damage in Osteoarthritis (OA) Pathogenesis. Supported by Gazi University Research Foundation No: 01/2018-37.

2012-2018      Investigation of the antiapoptotic and protective effects of Olea europaea L. leaf extract, oleuropein and hydroxytyrosol on H9c2 myogenic cell lines in induced cytotoxicity models.. Supported by Gazi University Research Foundation No: 01/2012-70.

2012-2015     Research on antioxidative, anti-inflammatory and cytoprotective effects of phenolic herbal compounds against xhantine/xhanthine oxidase-induced cellular stress in cardiomyocyte cultures in vitro. Supported by Gazi University Research Foundation No: 01/2012-53.

2011-2014         The effects of "(±)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester" on viability, reactive radical production, insulin releasing and cytokine-mediated cell death in INS-1 cells. Supported by Gazi University Research Foundation No: 01/2011-09.

2010-2013         The effects of SM1EC1 on glycoxidative stress markers and vascular reactivity on aging rats with or without diabetes. Supported by Gazi University Research Foundation No: 01/2010-126.

2007-2010        The effects of dietary restriction, exercise, orlistate and sibutramin on oxidative stress and antioxidation markers in obese patients. Supported by Gazi University Research Foundation No: 01/2007-02.

2004-2010          The vascular effects (in vivo and in vitro) of pyridoindole antioxidants on animal model of diabetes mellitus. Supported by Gazi University Research Foundation No: 01/2004-42.

2003-2009          Assesment of cardiovascular and Renovascular effects of antioxidant stobadine. Supported by Gazi University Research Foundation No: 01/2003-50.

1998-2001          The role of some antioxidant compounds on the         treatment of cardiovascular observed in experimental diabetes. Supported by    Ankara University Research Foundation No: 98-03-005.

1993-1994         Effects of antioxidant treatment on the nerve dysfunction in STZ-diabetic rats; comparison with essential fatty acids. Supported by grants from the William Harvey Research Institute, Ono Pharmaceuticals. and Scotia Pharmaceutical.

1993-1994        Effects of aminoguanidine treatment on sciatic nerve Doppler flux and in vitro prostacycline release in experimental diabetes. Supported by grants from the William Harvey Research Institute and Ono Pharmaceuticals.

1993-1994         The effects of essential fatty acids and anti-oxidants on sciatic nerve dysfunction in streptozotocin-diabetic rats. Supported by grants from the William Harvey Research Institute and Ono Pharmaceuticals.

1988-1990        The role of endothelial cells on vascular reactivity in alloxan diabetic rats. Supported by Ankara Univ. Research Found. No: 88-03-003.

DİĞER/ULUSAL

2011-2013          Development of Functional Nutrient, Dietary Supplement and OTC drug (pharmaceutical Formulations) from Olive leaf extracts. Supported by KOSGEB No: 2011-0850.