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ÖZGEÇMİŞ

 

Zübeyir ELMAZOĞLU

 

 

KİŞİSEL BİLGİLER

 

Adı Soyadı

Güncel Adres (TR)

 

Telefon

E-mail 

Doğum Yılı/Adresi

Uyruk

 

 

Zübeyir ELMAZOĞLU

Üniversiteler Mahallesi, Orta Doğu Teknik Üniversitesi, Kimya Bölümü

0506 924 77 12

z.elmazoglu@gmail.com; zub_pharma@hotmail.com  

03.09.1989/ Lefkoşa-KKTC

KKTC-TC

 

EĞİTİM BİLGİLERİ

2020- Doktora Sonrası Araştırmacı (AB Proje Personeli)

Orta Doğu Teknik Üniversitesi, Fen ve Edebiyat Fakültesi, Kimya Bölümü, Türkiye

 

2014 - 2020 Doktora

Gazi Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Türkiye

 

2011 - 2014 Yüksek Lisans

Gazi Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı (Tezli), Türkiye

 

2006 - 2011

Ankara Üniversitesi, Eczacılık Fakültesi, Türkiye

 

Dil/ Eğitim Sınavları

Ana Dil

Yabancı Dil

 

Türkçe

İngilizce (YÖK Dil: 93,750/100)

ALES

76,48932/ 100 (SAY)

YAPTIĞI TEZLER

 

2020 - Doktora

“Gluko-Lipotoksisite ile İndüklenmiş, Amiloid-β aracılı Nörodejenerasyonda Endokannabinoid Sistemin Rolünün Değerlendirilmesi”,  Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Farmakoloji AbD

2014 - Yüksek Lisans

“Mutant ve Yabanıl Tip HCT-116 Kolon Kanser Hücre Hatlarında Farnesil Transferaz İnhibitörünün Apoptotik Ve Anti-Proliferatif Etkilerinin Araştırılması”, Gazi Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyoloji ve Genetik AbD

2011 - Lisans

“Ras Onkojen Protein İnhibitörü Olan Farnesiltiyosalisilik Asit/ Farnesilantranilik Asit Türevi Yeni Bileşiklerin Sentezi ve Antikanser Aktivitelerinin Değerlendirilmesi”, Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya AbD

 

GÖREV ALINAN PROJELER/ÇALIŞMALAR

“Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity”, European Research Council (ERC) Project, INFRADYNAMICS-Gunbas Lab, Middle East Technical University, Department of Chemistry, Post-Doc, 2020-

 

“Nazal ANTI-COV Aşısının İmmünojenisite, Güvenliliği ve Toksisitesinin İncelendiği Plasebo Kontrollü Çift Kör Randomize Faz I Klinik Çalışma”, Sponsor: Nanografi Nano Teknoloji A.Ş., Buluşcu-Danışman, 2020-

 

“Kolloidal Platin Nanopartiküllerinin Lipopolisakkarit ile İndüklenen Nöroenflamasyon Üzerine Olan Potansiyel Etkilerinin ve Etki Mekanizmalarının Araştırılması”, TÜBİTAK-1002, Proje No: 219S166, Yardımcı Araştırmacı (Doktora öğrencisi), 2019-

 

“Gluko-Lipotoksisite ile İndüklenmiş, Amiloid-β aracılı Nörodejenerasyonda Endokannabinoid Sistemin Rolünün Değerlendirilmesi”, Doktora Tez Projesi, Gazi Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji AbD, CSRS-Lab, Araştırmacı, 2017-2020

 

“İnflamatuvar Nörodejenerasyonda Kannabinoid Reseptör Sinyalinin Hedeflenmesi: Redoks-Aracılı Yolakların Rolü”, 2552- TUBITAK-CONACYT İkili İşbirliği Programı, No: 315S088, Gazi Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji AbD, CSRS-Lab, Bursiyer (2017-2020), proje çalışmaları halen devam ediyor

 

“Diyabet-, Inflamasyon- ve Yaşa-bağımlı Nörodejenerasyonda Gliko-Lipotoksisitenin Moleküler Yolaklarının Karboksimetillenmiş Merkaptotriazino indolik Yeni Aldo-Keto Redüktaz (AKR1B1) Inhibitörleri ile Hedeflenmesi”, 2540- SBAG-SLOVAK Tematik İşbirliği Programı, Proje No: 215S197, Yardımcı Araştırmacı (Doktora öğrencisi), 2016-2020

 

“Osteoartrit Patogenezinde Redoks Modülatör Ajanların Rejeneratif Etki ve Etki Mekanizmalarının Araştırılması” , TUBİTAK-1001, Proje No: 315S012, Yardımcı Araştırmacı (Doktora öğrencisi), 2016-2020

 

“Personalized Nutrition in aging society: redox control of major age-related diseases”, NutRedOx, European Science Foundation, CA COST Action CA16112, 2016-

 

“Gazi Universitesi Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı Laboratuvar Cihazlarının (inkübatör) Bakım ve Onarımı”, Gazi Üniversitesi Bap No: 01/2019-24, Araştırmacı, 2019-2020

 

“Gazi Universitesi Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı Laboratuvar Cihazlarının (mikroskop) Bakım ve Onarımı”, Gazi Üniversitesi Bap No: 01/2019-01, Araştırmacı, 2019-2020

 

“Osteoartrit (OA) Patogenezinde Polifenolik Bileşiklerin Redoks Stres Aracılı Hasara Karşı Rejeneratif Etkileri ve Etki Mekanizmalarının Araştırılması.”, Gazi Üniversitesi Bap No: 01/2018-37  Gazi Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji AbD, CSRS-Lab, Yardımcı Araştırmacı(Doktora öğrencisi), 2018-2020

 

“Amiloid Beta Peptid1-42 ile Oluşturulan Deneysel Alzheimer Modelinde PSD-95 İnhibitörü Tat-N-Dimer’in Nöronal Koruma, Öğrenme ve Hafıza Fonksiyonları Üzerine Etkisi”,  TUBİTAK-3001, Proje No: 114S827, Yardımcı Araştırmacı (Yüksek lisans öğrencisi), 2014-2016

 

“Mutant ve Yabanıl Tip HCT-116 Kolon Kanser Hücre Hatlarında Farnesil Transferaz İnhibitörünün Apoptotik ve Anti-Proliferatif Etkilerinin Araştırılması”, Gazi Üniversitesi BAP No: 01-2012/50, Yüksek Lisans Tez Projesi, Araştırmacı, 2012-2014

 

“Ras Onkojen Protein İnhibitörü Olan Farnesiltiyosalisilik Asit/ Farnesilantranilik Asit Türevi Yeni Bileşiklerin Sentezi ve Antikanser Aktivitelerinin Değerlendirilmesi”, Ankara Üniversitesi Bap no: 10Ö3336001, Lisans Tez Projesi, Araştırmacı (Lisans öğrencisi), 2010-2011

 

Yayınlar & Eserler

 

SCI, SSCI VE AHCI İNDEKSLERİNE GİREN DERGİLERDE YAYINLANAN MAKALELER

 

  1. Elmazoglu, Z., Kayhan, H., Santamaría, A., Rangel-López, E., Uğur, P. K., Ceylan, A., Aschner, M., & Karasu, Ç. (2021). Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis. Neurochemical research, 10.1007/s11064-021-03434-7. Advance online publication. https://doi.org/10.1007/s11064-021-03434-7

 

  1. Seymen, C. M., Yar Sağlam, A. S., Elmazoğlu, Z., Arık, G. N., & Take Kaplanoğlu, G. (2021). Involvement of endometrial IGF-1R/IGF-1/Bcl-2 pathways in experimental polycystic ovary syndrome: Identification of the regulatory effect of melatonin. Tissue & cell, 73, 101585. Advance online publication. https://doi.org/10.1016/j.tice.2021.101585

 

  1. Cetin, S., Elmazoglu, Z., Karaman, O., Gunduz, H., Gunbas, G., & Kolemen, S. (2021). Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents. ACS Medicinal Chemistry Letters, 12(5), 752–757. https://doi.org/10.1021/acsmedchemlett.1c00018

 

  1. Elmazoglu, Z., Aydın Bek, Z., Saribas, S. G., Özoğul, C., Goker, B., Bitik, B., Aktekin, C. N., & Karasu, Ç. (2021). S-Allylcysteine Inhibits Chondrocyte Inflammation to Reduce Human Osteoarthritis via Targeting RAGE, TLR4, JNK and Nrf2 Signaling: Comparison with Colchicine. Biochemistry and cell biology = Biochimie et biologie cellulaire, 10.1139/bcb-2021-0004. Advance online publication. https://doi.org/10.1139/bcb-2021-0004

 

  1. Elmazoglu, Z., Prnova, M. S., Stefek, M., Ceylan, A. F., Aschner, M., Rangel-López, E., Santamaria, A., & Karasu, C. (2021). Protective Effects of Novel Substituted Triazinoindole Inhibitors of Aldose Reductase and Epalrestat in Neuron-like PC12 Cells and BV2 Rodent Microglial Cells Exposed to Toxic Models of Oxidative Stress: Comparison with the Pyridoindole Antioxidant Stobadine. Neurotoxicity Research, 10.1007/s12640-021-00349-7.

 

  1. Elmazoglu, Z., Galván-Arzate, S., Aschner, M., Rangel-López, E., Bayraktar, O., Santamaría, A., & Karasu, Ç. (2021). Redox-active phytoconstituents ameliorate cell damage and inflammation in rat hippocampal neurons exposed to hyperglycemia+Aβ1-42 peptide. Neurochemistry International, 145, 104993.

 

  1. Elmazoglu, Z., Prnova, M. S., Santamaria, A., Stefek, M., & Karasu, C. (2021). Combatting Nitrosative Stress and Inflammation with Novel Substituted Triazinoindole Inhibitors of Aldose Reductase in PC12 Cells Exposed to 6-Hydroxydopamine Plus High Glucose. Neurotoxicity Research, 39(2), 210–226.

 

  1. Elmazoglu, Z., Bek, Z. A., Sarıbaş, G. S., Özoğul, C., Goker, B., Bitik, B., Aktekin, C.N., & Karasu, Ç. (2020). TLR4, RAGE, and p‐JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox‐sensitive phenolic olive compounds: Comparison with ibuprofen. Journal of Tissue Engineering and Regenerative Medicine, 14: 1841– 1857.

 

  1. Elmazoglu, Z., Rangel-López, E., Medina-Campos, O. N., Pedraza-Chaverri, J., Túnez, I., Aschner, M., Santamaria, A., & Karasu, Ç. (2020). Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+ Aβ1-42 peptide in rat hippocampal neurons. Neurochemistry International, 140, 104817.

 

  1. Ozlu, H., Cakir Gundogdu, A., Elmazoglu, Z., Take Kaplanoglu, G., Oktar, L., & Karasu, C. (2020). Bacopa Monnieri Protects the Directly Affected Organ as Well as Distant Organs Against I/R Injury by Modulating Anti-Inflammatory and Anti-Nitrosative Pathways in A Rat Model for Infra-Renal Aortic Occlusion. Journal of Investigative Surgery, 1–12.

 

  1. Ergun, S. B., Saribas, G. S., Yarayici, S., Elmazoglu, Z., Cardak, A., Ozogul, C., Ilhan, M. N., Karasu, C., and Evren Kemer, O. (2019). Comparison of Efficacy and Safety of Two Tea Tree Oil-Based Formulations in Patients with Chronic Blepharitis: A Double-Blinded Randomized Clinical Trial. Ocular Immunology and Inflammation, 1–10.

 

  1. Elmazoglu, Z., Yar Saglam, A. S., Sonmez, C., & Karasu, C. (2020). Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson's disease and inflammatory pathways. Drug and Chemical Toxicology, 43(1), 96–103.

 

  1. Prnová, M. Š., Račková, L., Kováčiková, L., Balleková, J., Viskupičová, J., Micháliková, S., Taskoparan, B., Elmazoglu, Z., Rižner, T. L., Karasu, C., & Banerjee, S. (2019). General toxicity assessment of the novel aldose reductase inhibitor cemtirestat. Interdisciplinary Toxicology, 12(3), 120-128.

 

  1. Prnova, M. S., Kovacikova, L., Svik, K., Bezek, S., Elmazoglu, Z., Karasu, C., & Stefek, M. (2019). Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat-another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 10.1007/s00210-019-01769.

 

  1. Seymen, C. M., Ilgaz, C., Erdogan, D., Elmas, C., Saglam, A., Elmazoglu, Z., Aral, B. S., and Kaplanoglu, G. T. (2019). Melatonin Modulates NMDA-Receptor 2B/Calpain-1/ Caspase-12 Pathways in Rat Brain After Long Time Exposure to GSM Radiation. Turkish Neurosurgery, 29(6), 887–900.

 

  1. Aguilera-Portillo, G., Rangel-López, E., Villeda-Hernández, J., Chavarría, A., Castellanos, P., Elmazoglu, Z., Karasu, Ç., Túnez, I., Pedraza, G., Königsberg, M., & Santamaría, A. (2019). The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation. Molecular Neurobiology, 56(2), 844–856.

 

  1. Saglam, A. S., Alp, E., Elmazoglu, Z., & Menevse, E. S. (2016). Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. Oncology Letters, 12(4), 2463–2474.

 

  1. Yar Saglam, A. S., Alp, E., Elmazoglu, Z., & Menevse, S. (2016). Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. Human & Experimental Toxicology, 35(5), 526–543.

 

DİĞER DERGİLERDE YAYINLANAN MAKALELER

 

  1. Sağlam, ASY, Elmazoğlu, Z., Kayhan, H., Önen, Hİ, Yılmaz, A., Menevşe, ES. EF24’ün Dosetaksel ile Sıralı Uygulamasının Metastatik Meme Kanser Hücre Hattına Etkisi. Firat Tip Dergisi, 2018; 23(2)

 

  1. Elmazoglu, Z., Ergin, V., Sahin, E., Kayhan, H., & Karasu, C. (2017). Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response. Interdisciplinary Toxicology, 10(4), 129–141.

 

HAKEMLİ KONGRE / SEMPOZYUM BİLDİRİ KİTAPLARINDA YER ALAN YAYINLAR

 

  1. Seymen CM, Yar Saglam  A, Elmazoglu Z, Take Kaplanoglu G. Involvement of Endometrial IGF-1R/IGF-1/Bcl-2 Pathways In Endometrial Polycystic Ovary Syndrome: Identification Of The Regulatory Effect Of Melatonin. (Sözlü Sunum) International Eurasian Conference On Biotechnology and Biochemistry, 16 December 2020.

 

  1. Elmazoglu Z, Goker B, Bek ZA, Aktekin CN, Bitik B & Karasu, C. (2020). Standardized extract of Olea europaea leaves suppresses pro-inflammatory cytokines through regulating redox signaling pathways in human chondrocytes. (Poster Sunumu) Osteoarthritis and Cartilage, 28, S105-S106. Osteoarthritis Research Society International (OARSI) 2020 World Congress , Vienna, Austria. 30 April- 5 May 2020.

 

  1. Elmazoglu Z, Goker B, Bitik B, Aktekin CN, Yapar D & Karasu, C. (2020). Colchicine provides chondrocyte survival as a redox modulator in human osteoarthritis. (Poster Sunumu) Osteoarthritis and Cartilage, 28, S105. Osteoarthritis Research Society International (OARSI) 2020 World Congress , 30 April- 5 May 2020, Vienna-Austria.

 

  1. Elmazoglu Z, Kovacikova L, Prnova MS, Stefek M, Santamaria A, Karasu C. Cemtirestat Ameliorates Aβ1-42 -Mediated Injury in High Glucose-Induced Neuronal Injury: Type 3 Diabetes in vitro Model. (Sözlü Sunum) Türk Farmakoloji Derneği 25. Ulusal Farmakoloji Kongresi 9. Klinik Farmakoloji Sempozyumu 8. Klinik Toksikoloji Sempozyumu, 3-7 November 2019, Kusadasi-Turkey.

 

  1. Elmazoglu Z, Ceylan FA, Saribas GS, Kovacikova L, Prnova MS, Stefek M, Kaleci B, Dagistanli F, Ozogul C, Karasu C. Effects of Cemtirestat on Oxidative Stress and Tissue injury in a Rat Model of Diabetes Induced by High Fructose Diet and Streptozotocin: A Comperative Study with Stobadine and Epalrestat. (Sözlü Sunum), Türk Farmakoloji Derneği 25. Ulusal Farmakoloji Kongresi 9. Klinik Farmakoloji Sempozyumu 8. Klinik Toksikoloji Sempozyumu, 3-7 November 2019, Kusadasi-Turkey.

 

  1. Bek ZA, Elmazoglu Z, Göker B, Bitik B, Aktekin CN, Tezcan ME, Karasu C Dut Yaprağı (Morus alba L.) Standart Ekstresinin (ImmunFLEX®) ve Major Biyoaktif Komponentlerinden Deoksinojirimisin'in İnsan Osteoartritik Primer Kondrositler Üzerine Etkileri, in vitro. (Poster Sunumu) Türk Farmakoloji Derneği 25. Ulusal Farmakoloji Kongresi 9. Klinik Farmakoloji Sempozyumu 8. Klinik Toksikoloji Sempozyumu, 3-7 November 2019, Kusadasi-Turkey.

 

  1. Elmazoglu Z, Kovacikova L, Prnova MS, Stefek M, Karasu C. Novel Aldose Reductase Inhibitors, CMTI and COTI, Prevent 6-OHDA-Induced Cellular Neurotoxicity via Modulation of Redox Stress and Inflammation Pathways. (Sözlü Sunum) Türk Farmakoloji Derneği 25. Ulusal Farmakoloji Kongresi 9. Klinik Farmakoloji Sempozyumu 8. Klinik Toksikoloji Sempozyumu, 3-7 November 2019, Kusadasi-Turkey.

 

  1. Elmazoglu Z, Oguz D, Bek ZA, Rangel-López E, Santamaria A, Karasu C. S-Allyl-L-Cysteine and Luteolin Prevents Hyperglycemia Induced Aβ1-42  Injury in an Alzheimer’s Disease Cell Model. (Sözlü Sunum) COST Action NutRedOx-CA16112, 2nd-4th October 2019, Lisbon-Portugal.

 

  1. Elmazoglu Z, Saglam ASY, Menevse ES. LB42708, a Farnesyltransferase Inhibitor, Induces Apoptosis and Suppresses Cell Growth without Altering p-Akt (Ser473) in p53+/+ and p53-/- HCT-116 Cells. (Poster Sunumu) VII. International Congress of Molecular Medicine, 5-7 September 2019, Istanbul-Turkey.

 

  1. Elmazoglu Z, Ceylan Asli F, Kovacikova L, Soltesova Prnova M, Stefek M, Karasu C. Aldose reductase inhibitors in the prevention of diabetic neuro-degenerative diseases: studies in cell culture models of Alzheimer’s disease and Parkinson’s disease under hyperglycemic conditions. (Sözlü Sunum) Interdisciplinary Toxicology Volume 12 (Supplement 1) Page: 22 L-09.  24th Interdisciplinary Toxicology Conference (TOXCON 2019), 26-28 June 2019, Vyhne-Slovakia.

 

  1. Ceylan Asli F, Elmazoglu Z, Stefek M, Karasu C. Effects of cemtirestat on GSH/GSSG, caspase-3 and protein carbonyl of liver and lung in a rat model of diabetes induced by high fructose diet and streptozotocin: a comparative study with stobadine and epalrestat. (Sözlü Sunum) Interdisciplinary Toxicology Volume 12 (Supplement 1) Page: 22 L-10.  24th Interdisciplinary Toxicology Conference (TOXCON 2019), 26-28 June 2019, Vyhne-Slovakia.

 

  1. Afandiyeva N, Elmazoglu Z, Bek Aydin Z, Ceylan Asli F, Stefek M, Kavutcu M, Karasu C. Comparative effects of cemtirestat, stobadine and epalrestat on glutathione-s-transferase and catalase activities in the liver and lung of diabetic rats given high fructose diet and streptozotocin. (Poster Sunumu) Interdisciplinary Toxicology Volume 12 (Supplement 1) Page: 33.  24th Interdisciplinary Toxicology Conference (TOXCON 2019), 26-28 June 2019, Vyhne-Slovakia.

 

  1. Elmazoglu Z, Bek ZA, Göker B, Bitik B, Aktekin CN, Tezcan ME, Karasu C. AB0107 S-Allyl-L-Cysteine Attenuates Inflammation related Oxidative Stress Parameters and Increases Adhesion Capacity of Primary Human Osteoarthritic Articular Chondrocytes. (Poster Sunumu) Annals of the Rheumatic Diseases 2019; 78: 1514-1515. European Congress of Rheumatology (EULAR) 14-18 June 2019, Madrid-Spain.

 

  1. Elmazoglu Z, Kovacikova L, Stefek M, Karasu C. Novel Carboxymethylated Mercaptotriazinoindole Derivatives as Potential inhibitors of Aldo-Keto Reductase (AKR1B1) Ameliorate Hyperglycemia Mediated and 6-OHDA-induced Neurotoxicity in PC12 Cells: In Vitro Hyperglycemic Parkinson’s Disease Model. (Sözlü Sunum) (OP-52) The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Elmazoglu Z, Aydın Bek Z, Goker B, Aytekin CN,  Bitik B, Karasu C. Effects of Quercetin on Oxidative and inflammatory Stress Pathways in Human Osteoarthritic Chondrocytes. (Poster Sunumu) (PP-27) The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Aydın Bek Z, Elmazoglu Z, Goker B,  Bitik B, Aytekin CN, Karasu C. Icariin Inhibits Inflammatory Degeneration in Human Osteoarthritic Chondrocytes via Modulation of Redox Stress-induced Pathways. (Poster Sunumu) (PP-28)  The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Elmazoglu Z, Reihanifar T, Kovacikova L, Stefek M, Ceylan Isık A, Karasu C. Novel Aldo-Keto Reductase inhibitors Give Rise To Have A Great Potential on Regulating Hyperglycemia Excerbated Aβ1-42 Neurotoxicity in Primary Hippocampal Neurons. (Poster Sunumu) (PP-29) The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Elmazoglu Z, Rangel-López E, Santamaria A, Karasu C. Endogenous Cannabinoids Exerts Neuroprotective Functions against Aβ1-42- Mediated injury in Hippocampal Neurons Under Hyperglycemic Conditions. (Poster Sunumu) (PP-30) The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Elmazoglu Z, Rangel-López E, Santamaria A, Karasu C. The Synthetic Cannabinoid, CP 55,940, Has A Potential Redox Modulatory Effect on Aβ1-42-Mediated Injury in High Glucose-induced Neurotoxicity in Hippocampal Neurons. (Poster Sunumu) (PP-31) The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 April 2019, Cappadoica-Turkey.

 

  1. Elmazoglu Z, Rangel-López E, Santamaria A, Karasu C. Neuroprotective Effects of Active Phytoconstituents Against Aβ1-42 - Mediated Injury in High Glucose-Induced Primary Hippocampal Neurotoxicity: In Vitro Hyperglycemic Alzheimer’s Disease Model. (Sözlü Sunum) (OP-31) The Fifth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-5) 24-26 April 2019, Cappadocia-Turkey.
  2.  
  3. Aydın Bek Z, Elmazoglu Z, Goker B,  Bitik B, Aytekin CN, Karasu C. Therapeutic Potential of Olive Leaf Polyphenols (ZeyEX®) in Human Osteoarthritic Chondrocytes In Vitro. (Sözlü Sunum) (OP-80) The Fifth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-5) 24-26 April 2019, Cappadocia-Turkey.

 

  1. Aydın Bek Z, Elmazoglu Z, Goker B,  Bitik B, Aytekin CN, Karasu C. Effects of Mulberry (Morus alba L.) Leaf Extract (Immunflex®) on MMP-9, BMP-2 and COMP in Human Osteoarthritic Chondrocytes In Vitro. (Poster Sunumu) (PP-45) The Fifth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-5) 24-26 April 2019, Cappadocia-Turkey.

 

  1. Elmazoglu Z, Inan Z, Keskin C, Bozkurt Z, Calis I, Karasu C. Astragaloside IV and Forsythoside B Modulate Hyperglycemia-Mediated Neurotoxicity in Primary Hippocampal Neuronal Cells. (Poster Sunumu) (PP-46) The Fifth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-5), 24-26 April 2019, Cappadocia-Turkey.

 

  1. Elmazoglu Z, Aydın Bek Z,  Goker B,  Aytekin CN, Bitik B, Karasu C.Osteoartritik İnsan Kondrositlerinde, Oleuropein Ve Zeytin Yaprağı Polifenolik Bileşiklerinin (ZeyEX®) Kondroprotektif Etkileri (Poster Sunumu). 5-7 April 2019, Nevsehir-Turkey.

 

  1. Goker B, Elmazoglu Z, Bitik B, Aytekin CN, Karasu C. Luteolin Modulates Glyco-Lipo-Oxidative Protein Modifications and Inhibits Inflammatory Cytokine Release in Human Osteoarthritic Articular Chondrocytes: Comparison with Colchicine (Poster Sunumu) Arthritis Rheumatol 2018; 70 (suppl 10), ACR/ARHP Annual Meeting, 19-24 October 2018, Chicago, USA.

 

  1. Elmazoglu Z, Colakoglu M, Banerjee S, Bitik B, Aktekin CN, Goker B, Karasu C. AB0090 Verbascoside and hydroxytyrosol downregulate stress-related pathways in human osteoarthritic articular chondrocytes. (Poster Sunumu) Annals of the Rheumatic Diseases 2018;77:1241. European Congress of Rheumatology (EULAR), 13-16 June 2018, Amsterdam-Netherlands.

 

  1. Yücel GN, Seymen CM, Elmazoglu Z, Yar Sağlam A S, Sepici Dinçel A, Take Kaplanoğlu G. Melatonin Polikistik Over Sendromuna Bağlı İnfertilitede Yeni Bir Umut Olabilir mi? Deneysel Bir Çalışma. (Poster Sunumu), 14. Ulusal Histoloji ve Embriyoloji Kongresi, 13-18 May 2018, Antalya-Turkey.

 

  1. Yar Sağlam AS, Elmazoğlu Z, Güney Ş , Önen Hİ, Seymen CM, Take Kaplanoğlu G, Karasu Ç, Menevşe ES. Amiloid Beta Peptid 1-42 İle Oluşturulan Deneysel Alzheimer Modelinde PSD-95 İnhibitörünün Nöronal Koruma, Öğrenme Ve Hafıza Fonksiyonları Üzerine Etkisi.  (Sözlü Sunum) XV. Ulusal Tıbbi Biyoloji Ve Genetik Kongresi, 26 - 29 November 2017, Oludeniz-Fethiye.

 

  1. Yarayıcı S, Elmazoğlu Z, Yar Sağlam AS, Stefek M, Karasu C. Effects of a Novel Carboxymethylated Mercaptotriazinoindole Inhibitor of Aldo-Keto Reductase in in vitro Glucolipotoxicity model for Hippocampal Neurodegeneration. (Sözlü Sunum) FD 2017: The 67th Czech and Slovak Pharmacological Days. Programme & abstracts. Interdisciplinary toxicology. - Bratislava: Slovak Toxicology Society SETOX: Institute of Experimental Pharmacology and Toxicology SAS, 2017, vol. 10, suppl. 2, p. 53. 2-4 October 2017. The 67th Czech and Slovak Pharmacological Days, Stara Lesna-Slovakia.

 

  1. Elmazoglu Z, Karasu C. Protective Effects of Olive Polyphenols Against Neurotoxin-Induced cellular Model of Parkinson’s Disease. (Sözlü Sunum) FD 2017: The 67th Czech and Slovak Pharmacological Days. Programme & abstracts. Interdisciplinary toxicology. - Bratislava: Slovak Toxicology Society SETOX: Institute of Experimental Pharmacology and Toxicology SAS, 2017, vol. 10, suppl. 2, p. 22. 2-4 October 2017. The 67th Czech and Slovak Pharmacological Days, Stara Lesna-Slovakia.

 

  1. Elmazoglu Z, Yarayici S, Aydın Bek Z,  Aktekin CN, Bitik B, Goker B, Karasu C. Targeting Oxidative Degeneration by Redox Modulating Phytoconstituents in Osteoarthritic Articular Chondrocyte Cultures. (Poster Sunumu) FD 2017: The 67th Czech and Slovak Pharmacological Days. Programme & abstracts. Interdisciplinary toxicology. - Bratislava: Slovak Toxicology Society SETOX: Institute of Experimental Pharmacology and Toxicology SAS, 2017, vol. 10, suppl. 2, p. 30. 2-4 October 2017, The 67th Czech and Slovak Pharmacological Days, Stara Lesna-Slovakia.

 

  1. Elmazoglu Z, Yarayici S, Aktekin CN, Bitik B, Goker B, Karasu C. Targeting Redox Signaling by Phytophenols in Condrocytes Isolated from Human Osteoarthritic Articular Cartilage in vitro. (Poster Sunumu) The NutRedOx COST Action CA16112 & the 6th NutriOx Atelier, , P13, Page 11. 27-29 September 2017, Strasbourg-France.

 

  1. Derici MK, Saglam ASY, Kayhan H, Elmazoglu Z, Yilmaz ED, Yilmaz A. Effects of the Lanosterol Synthase Inhibition on Apoptosis and PI3K/AKT Signaling Pathway in HeLa Cells (Poster Sunumu) 1st International Congress on Cancer and Ion Channels, 21-23 September 2017, Sanli Urfa-Turkey.

 

  1. Saglam ASY, Elmazoglu Z, Kayhan H, Onen HI, Yilmaz A, Menevse ES. The Effects of Sequential Administration of EF24 with Docetaxel Apoptotic Response in Metastatic Breast Cancer Cell Line. (Sözlü Sunum) VI International Congress of Molecular Medicine, 22-25 May 2017, Istanbul-Turkey.

 

  1. Yildirim EF, Saglam ASY, Elmazoglu Z, Kayhan H, Onen HI. Apoptotic Effect of Anacardic Acid and Farnesyl Transferase Inhibitor on Metastatic Breast Cancer Cell Line (MCF-7). (Sözlü Sunum) VI International Congress of Molecular Medicine. 22- 25th May 2017, Istanbul-Turkey.

 

  1. Seymen CM, Celal I, Erdoğan D, Elmas Ç, Saglam ASY, Elmazoglu Z, Aral BS, Kaplanoğlu GK. Investigation the effects of chronic mobile phone radiation and melatonin used for protection purpose on the brain by using different methods (Sözlü Sunum) 14. Ulusal Sinirbilim Kongresi, 26-29 May 2016. An International Journal of Experimental and Clinical Anatomy 10 (Supp1) May 2016. Ankara-Turkey.

 

  1. Elmazoglu Z, Gurkan-Alp AS, Buyukbingol E. Synthesis of some novel N-substituted farnesylthiosalicylamide derivatives, (Poster Sunumu) 4th European Conference on Chemistry for Life Sciences (4ECCLS), 192 pp. (P50), 31 August - 3 September 2011, Budapest, Hungary.

 

 

 

Kongre ve Sertifikalar

  1. “Temel Laboratuvar Cihazları ve Ekipmanları Eğitimi”,  Dizge Analitik ve Biomedikal San.Tic.Ltd.Sti., Orta Doğu Teknik Üniversitesi, Kimya Bölümü, Ankara-Türkiye.
  1. “ZEISS LSM 900 ve Airyscan Kullanıcı Eğitimi”, Konfokal Mikroskop Eğitimi, Carl Zeiss Teknoloji Çözümleri Tic. Ltd. Şti, Orta Doğu Teknik Üniversitesi, Kimya Bölümü , 16-17 Temmuz 2020, Ankara-Türkiye
  1. Türk Farmakoloji Derneği 25. Ulusal Farmakoloji Kongresi 9. Klinik Farmakoloji Sempozyumu 8. Klinik Toksikoloji Sempozyumu, 3-7 Kasım 2019, Kuşadası-Türkiye
  1. The Fifth International Symposium on Pharmaceutical and Biomedical Sciences (ISPBS-5) 26-28 Nisan 2019, Kapadokya-Türkiye.
  1. The Fifth International Mediterranean Symposium on Medicinal and Aromatic Plants (MESMAP-5) 24-26 Nisan 2019, Kapadokya-Türkiye.
  1. “RS-G4 Confocal Microscopy Course”, MAVIG Research, Gazi Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı, 27-28 Şubat 2019, Ankara-Türkiye.
  1. The 67th Czech and Slovak Pharmacological Days. 2-4 Ekim 2017, Stará Lesná-Slovakya.
  1. ODTU Sinir Bilim Günleri, Ortadoğu Teknik Universitesi, 6-7 Mayıs 2017, Ankara-Türkiye.
  1. 2. ODTU Sinir Bilim Günü, Ortadoğu Teknik Universitesi, 24 Nisan 2016, Ankara-Türkiye.
  1. “XIIth Laboratory Animal Practice & Ethics Course”, Gazi University Animal Experiments Local Ethics Commitee, 10-20 Aralık 2012, Ankara- Türkiye.
  1. 10th International Symposium on Pharmaceutical Sciences (ISOPS-10), Ankara University Faculty of Pharmacy, 26-29 Haziran 2012 , Ankara-Türkiye.

Ödüller

“Best Oral Presentation” Award, The 5th International Mediterranean Symposium on Medicinal and Aromatic Plants & The 5th International Symposium on Pharmaceutical and Biomedical Sciences Joint Meeting, (Ödül) 24-28 Nisan 2019, Kapadokya-Türkiye.

“Comet Assay Course”, The NutRedOx COST Action CA16112 and MAESTRO Project (2014/14/A/ST4/00640), Gdansk University of Technology, 5-7 Şubat 2019, Gdansk-Polonya.

Scientific and Technological Research Council of Turkey (TUBITAK) and The National Council of Science and Technology (CONACYT) Joint Project entitled “Targeting cannabinoid receptor signalling in inflammatory neurodegeneration: a potential role for redox-mediated pathways” 2552- TUBITAK-CONACYT, Grant No: 315S088, (Burs) 2017-2020.

 

 

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